Table 1. Values of acute toxicity for cofalginum, rheopyrin, novalginum, and benalginum solutions determined by plant and animal test organ
Studied solutionsAnimal bioassaysPlant bioassay
Ceriodaphnia-mortality, 48 hHydra-lethality, 48 hCrucian carp-mortality, 96 hOnion-root length relative to control, 96 h
Control0%0%0%100%
Cofalginum (metamizole sodium:caffeine-benzoate sodium=6:1) 4,375 mg/ml80% (24 h)
100% (48 h)
100% (24 h)100% (24 h)8%
Rheopyrin (phenylbutozone:aminophenazone=1:1) 3,125 mg/ml100% (12 h)100% (96 h)100% (2 h)2,2%
Novalginum (propyphenazone:acetaminophen:caffeine=4:4:1) 3,125 mg/ml100% (12 h)100% (48 h)100% (1,5 h)0%
Benalginum (metamizole sodium:caffeine:thiamine hydrochloride=13:13:1) 6,875 mg/ml100% (12 h)100% (48 h)100% (1 h)3,8%