MORPHOMETRIC CHARACTERISTIC OF MYELINATED NERVE FIBRES IN THE EXPERIMENTAL VINCRISTINE-INDUCED PERIPHERAL NEUROPATHY

S.B. Gerashchenko

The alterations of the sciatic nerve myeloarchitectonics have been studied in white rats by using the methods of computer morphometric analysis. Peripheral neuropathy was caused by intravenous administration of vincristine (10 daily injections at dose of 100 mkg/kg). The total dose 1000,0 mkg/kg of vincristine was found to cause progressive disorganization of myelinated nerve fibres which manifested by the disturbance of metric characteristics of axis cylinders and myelin sheath. The major morphologic manifestation of neuropathy was the swelling of axoplasm of myelinated nerve fibres of various diameter and myelin sheath edema. Vincristine-induced peripheral neuropathy is a long term process when the period of relative compensation lastig about 3 weeks gradually turns into decompensation with its typical corrugation and deformation of axis cylinders.

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