MOLECULAR-GENETIC ASPECTS OF THE PSYCHONUTRIENTOLOGY (PART 1): NEUROPROTECTION MECHASNISM OF DIETARY RESTRICTION

V.N. Zalessky, N.V. Velikaja

Dietary restriction (reduced caloric intake with nutritional mainyenance) can extend vulnerability of nervous and my increase the resistance of the nervous system to age-related diseases, including neurodegenerative disorders, ischemic insults and other, with the psychonutrientologic prophylaxis. The molecular-genetic mechanisms of the neuroprotection effects of dietsry restriction involle stimulation of the expession of neurotrophic factors and "stress" proteins ("shaperons"), with by suppressing oxyradical production, stabilizing cellular calcium homeostasis and inhibiting of apeptosis, also increase neuroplasticity proucess increase number newly-generated neural stem cells and self-repair. A better understanding of the cellular and molecular mechanisms due to dietary restriction can be optimise therapevtic programms nutrient-relovted neuropsychological rheabilitation of patients with neurogenerative diseases in geriatric clinic.

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