MOLECULAR MECHANISMS OF NUTRIENTDEPENDANT REGULATION OF GENE EXPRESSION AND DNA STABILIZATION: BASICS OF DIETOMICS

V.N. Zalessky, N.V. Velikaja, О.B. Dynnik

The understanding of the role of nutrients on the gene expression, repair and DNA stability processes in cells recently became more prominent in nutritional science. The study on single effects of nutrients on the individual's phenotype as well as the serial analyses of gene expression patterns in response to specific nutrients help us to understand how metabolic homeostasis is maintained. Considering that there is wide variation in the ability of nutritional factors to modulate the expression of detrimental or protective proteins at an individual level, the concept of diet-medication could be developed in the light of a better understanding of nutrient-gene interaction. Further more, as several vitamins participate in DNA protection and genomic stabilization, diet-linked therapies could become part of cancer, cardiovascular and other treatment with relevant consequences for human health.

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